Jamie Osborne, Jacob Stockdale, Tadhg Furlong and Ryan Baird have been ruled out of Ireland's autumn finale against Australia.
After defeats to New Zealand, Australia and South Africa, where does a challenging autumn leave England and Steve Borthwick?
Eddie Jones has made light of claims made by Danny Care over his behaviour as England head coach.
England ran in nine tries as they cruised to a 59-14 victory over Japan at Allianz Stadium, Twickenham, ending their Autumn Nations Series with a win.
Recap from England's Autumn Nations Series international against Japan at Allianz Stadium, Twickenham. where the home outfit romped to a 59-14 win.
Wales slumped to a 12th successive Test match defeat as a 45-12 loss to world champions South Africa ramped up the pressure on head coach Warren Gatland.
Gus McCarthy scored a debut try and Mack Hansen touched down twice as Ireland set aside their unconvincing start to the autumn with a 52-17 win over Fiji in Dublin.
Ellis Genge says "good bloke" Eddie Jones will "have tricks up his sleeve" and relish the occasion when he coaches Japan against England on Sunday.
Eddie Jones pulled out of his pre-match press conference due to "health reasons" ahead of Japan's meeting with his former England side.
Ireland captain Caelan Doris feels fighting talk from the Fiji camp has added an extra edge to Saturday's Autumn Nations Series showdown in Dublin.
George Furbank and Tom Curry will both return for England against Japan after Steve Borthwick made two changes to his starting XV to face Eddie Jones’ side.
Uncapped duo Gus McCarthy and Cormac Izuchukwu have been named in Ireland's starting XV for Saturday's Autumn Nations Series match against Fiji in Dublin.
England assistant coach Andrew Strawbridge admitted that they are feeling the pressure to end their losing streak ahead of Sunday’s Test against Eddie Jones' Japan.
Wales head coach Warren Gatland stressed he "absolutely" wants to continue in the job but said "decisions could be made outside of my control".
What does the future look like for Wales and coach Warren Gatland amid their record losing run? Sky Sports News' James Cole assesses the situation.
Cadan Murley and Tom Curry have been called up to the England squad ahead of their Test match against Japan at Twickenham on Sunday.
Wales head coach Warren Gatland says he will consider his future after his side tumbled to a record 11th consecutive Test match defeat.
Wales suffered a record 11th successive defeat as Australia inflicted a 52-20 home hammering in Cardiff to ramp up the pressure on head coach Warren Gatland.
France shook off a slow start to beat New Zealand 30-29 for a record-tying third straight time in a bruising autumn rugby test at Stade de France on Saturday.
England head coach Steve Borthwick says he has the full backing of the RFU's management to help turn around his side's run of poor form in the long term.
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